TABLE 2

Fasting plasma insulin and lipid levels before and after 3 months of 600 mg/day troglitazone

Lean
Obese
Type 2 diabetes
Before TZDAfter TZDBefore TZDAfter TZDBefore TZDAfter TZD
Insulin (mU/l)4.3 ± 0.54.1 ± 0.816 ± 2.7*12.5 ± 2.520.6 ± 4.616.2 ± 5.3
NEFA (mmol/l)0.4 ± 0.060.4 ± 0.050.39 ± 0.040.37 ± 0.050.58 ± 0.06*0.51 ± 0.05
Triglyceride mg/dl)102 ± 20112 ± 27211 ± 48173 ± 38271 ± 55169 ± 28
Total cholesterol (mg/dl)175 ± 8177 ± 13180 ± 7194 ± 7197 ± 14191 ± 12
HDL cholesterol (mg/dl)57 ± 754 ± 736 ± 239 ± 337 ± 2§47 ± 5
  • Data are means ± SE.

  • *

    * P < 0.05,

  • P < 0.005 compared with lean control subjects before TZD treatment.

  • P < 0.05 compared with values before TZD treatment within groups.

  • §

    § P < 0.001 compared with lean control subjects before TZD treatment.

  • P < 0.01 compared with values before TZD treatment within groups.