TABLE 1

Effect of CHIR99021 treatment on plasma glucose and insulin concentrations, glucose infusion rate, glucose disposal, and EGP during euglycemic-hyperinsulinemic clamps in prediabetic ZDF (fa/fa) rats.

Insulin Infusion rate
2 mU · kg−1 · min−1
20 mU · kg−1 · min−1
ControlCHIR99021 treatedControlCHIR99021 treated
Glucose (mmol/l)
 Basal5.7 ± 0.36.3 ± 0.36.8 ± 0.26.2 ± 0.2
 Clamp7.1 ± 0.36.8 ± 0.35.6 ± 0.25.8 ± 0.3
Insulin (pmol/l)
 Basal535 ± 85671 ± 78571 ± 123718 ± 135
 Clamp542 ± 59660 ± 646513 ± 709*6107 ± 386*
Glucose infusion rates (μmol · kg−1 · min−1)
 Basal0000
 Clamp8.3 ± 2.311.2 ± 3.196.8 ± 4.985.1 ± 5.0
Glucose disposal (μmol · kg−1 · min−1)
 Basal83.4 ± 7.980.4 ± 9.872.1 ± 9.065.1 ± 12.1
 Clamp89.8 ± 9.178.4 ± 9.1125.3 ± 12.0*117.4 ± 12.0*
EGP (μmol · kg−1 · min−1)
 Basal83.4 ± 7.980.4 ± 9.872.1 ± 9.065.1 ± 12.1
 Clamp81.6 ± 10.767.2 ± 9.1*28.5 ± 9.7*32.3 ± 16.7*
  • Data are means ± SE.

  • *

    * P < 0.05 compared to basal.