TABLE 2

Effect of 20-h preinfusion on basal plasma glucose and insulin concentrations, and glucose infusion rates during euglycemic-hyperinsulinemic clamps in diabetic ZDF (fa/fa) rats.

8 mU · kg−1 · min−1 insulin infusion rate
ControlCHIR99021 treated
Glucose (mmol/l)
 Basal11.7 ± 1.35.8 ± 1.2
 Clamp5.9 ± 0.35.1 ± 0.4
Insulin (pmol/l)
 Basal387 ± 58319 ± 54
 Clamp1266 ± 316*776 ± 192*
Glucose infusion rates (μmol · kg−1 · min−1)
 Clamp75.0 ± 10.872.3 ± 7.8
  • Data are means ± SE.

  • *

    * P < 0.05 compared to basal.