TABLE 1

Arterial plasma levels of norepinephrine, epinephrine, and cortisol before and after oral administration of BAY R 3401 in the presence of non-insulin-induced hypoglycemia with and without mild hyperinsulinemia and in the presence of euglycemia with and without mild hyperinsulinemia in 18-h-fasted conscious dogs

GroupControl periodBAY R 3401 with or without peripheral glucose and/or insulin infusion (min)
1020306090120180
Hypoglycemia
 Norepinephrine (pmol/l)981 ± 177993 ± 171898 ± 1711,069 ± 1361,011 ± 100969 ± 1241,046 ± 1301,099 ± 254
 Epinephrine (pmol/l)426 ± 60513 ± 98437 ± 98475 ± 71458 ± 87458 ± 60431 ± 82453 ± 93
 Cortisol (nmol/l)41 ± 850 ± 1155 ± 1158 ± 1750 ± 847 ± 863 ± 1966 ± 33
Hypoglycemia + insulin
 Norepinephrine (pmol/l)1,454 ± 2421,188 ± 2721,336 ± 2721,543 ± 2721,714 ± 3131,720 ± 2661,667 ± 2191,856 ± 242
 Epinephrine (pmol/l)758 ± 147519 ± 98415 ± 98770 ± 153857 ± 153830 ± 158961 ± 1041,037 ± 191
 Cortisol (nmol/l)50 ± 1452 ± 1150 ± 1174 ± 1988 ± 2299 ± 19*99 ± 19*74 ± 14
Euglycemia
 Norepinephrine (pmol/l)881 ± 207946 ± 154934 ± 154786 ± 183798 ± 154893 ± 201822 ± 195851 ± 177
 Epinephrine (pmol/l)420 ± 180409 ± 87284 ± 87295 ± 115273 ± 33272 ± 175218 ± 104442 ± 196
 Cortisol (nmol/l)58 ± 1461 ± 1458 ± 1455 ± 2236 ± 647 ± 855 ± 1474 ± 36
Euglycemia + insulin
 Norepinephrine (pmol/l)940 ± 100916 ± 891011 ± 136958 ± 1061058 ± 166916 ± 1121023 ± 1421383 ± 148
 Epinephrine (pmol/l)524 ± 136551 ± 142579 ± 158579 ± 175633 ± 186464 ± 109475 ± 164628 ± 218
 Cortisol (nmol/l)58 ± 1166 ± 863 ± 894 ± 14*91 ± 11*77 ± 388 ± 27110 ± 19*
  • Data for each group are means ± SE from five dogs.

  • *

    * Significantly changed from the values during the control period in the same group.