Metabolic characteristics of ZDF rats
| BASAL | CLAMP | |||||
|---|---|---|---|---|---|---|
| ZDVF+ | ZDVF− | ZDVF+ | ZDVF− | |||
| n | 6 | 6 | 6 | 6 | ||
| Glucose (mmol/l) | 8.9 ± 0.4 | 8.5 ± 0.5 | 10.1 ± 0.7* | 8.4 ± 0.3 | ||
| Insulin (pmol/l) | 76 ± 9* | 44 ± 2 | 112 ± 10 | 101 ± 5 | ||
| FFA (mmol/l) | 1.99 ± 0.22 | 1.67 ± 0.13 | 2.53 ± 0.11* | 1.51 ± 0.16 | ||
| GIR (mg · kg−1 · min−1) | 0 | 0 | 0 | 2.1 ± 0.6 | ||
| EGP (mg · kg−1 · min−1) | 13.8 ± 0.8 | 13.1 ± 1.6 | 13.3 ± 0.5* | 10.7 ± 0.6† | ||
| Rd (mg · kg−1 · min−1) | 13.8 ± 0.8 | 13.1 ± 1.6 | 13.7 ± 0.8 | 14.2 ± 0.8 | ||
Plasma glucose, insulin, FFA levels, glucose infusion rate (GIR), EGP, and glucose uptake (Rd) at basal conditions and during the pancreatic clamps in ZDVF+ (no VF removed) and ZDVF− (VF removed) rats.
* P < 0.001 vs. ZDVF−,
† P < 0.001 vs. basal. All data are presented as means ± SE.