TABLE 2

Structural data on 50 type 1 diabetic patients compared with 10 nondiabetic control subjects, and type 1 diabetic patients with microalbuminuria (AER <200 μg/min) compared with those with clinical proteinuria (AER ≥200 μg/min)

All patients (A)Control subjects (C)P A vs. CAER <200 (M)AER ≥200 (P)P
M vs. PM vs. CP vs. C
n50103218
MGV (× 106 μm3)4.00 (3.65–4.34)3.16 (2.34–3.97)0.0503.64 (3.26–4.01)4.64 (4.03–5.25)0.0040.2370.005
GBM surface (mm2)0.50 (0.46–0.54)0.55 (0.46–0.63)0.3510.49 (0.43–0.56)0.51 (0.43–0.59)0.7020.3330.472
Nmes/glom1,432 (1,241–1,491)768 (609–927)<0.0011,277 (1,049–1,505)1,708 (1,373–2,042)0.029<0.001<0.001
Nendo/glom1,368 (1,245–1,491)1,003 (849–1,157)<0.0011,271 (1,121–1,421)1,541 (1,335–1,748)0.0320.0120.001
Npodo/glom524 (485–562)580 (487–672)0.233536 (490–581)502 (426–578)0.4090.3420.187
Nvmes/glom ×106 μm−3350 (319–381)245 (199–292)0.007342 (300–384)364 (317–411)0.5060.0220.002
Nvendo/glom ×106 μm−3345 (327–362)331 (269–393)0.561350 (327–373)335 (307–363)0.4250.4660.872
Nvpodo/glom ×106 μm−3146 (127–165)193 (157–230)0.052163 (136–189)116 (92–140)0.0190.2450.001
  • Data are means (95% CI). GBM surface, surface area of glomerular basement membrane underlying podocytes (filtration surface area + mesangio-urinary surface area); Nmes/glom, mesangial cell number per glomerulus; Nendo/glom, endothelial cell number per glomerulus; Npodo/glom, podocyte number per glomerulus; Nvmes/glom, mesangial cell density per glomerulus; Nvendo/glom, endothelial cell density per glomerulus; Nvpodo/glom, podocyte density per glomerulus.