TABLE 3

Structural data on 16 type 1 diabetic patients at baseline and after 3 years and compared with 10 nondiabetic subjects

Baseline (B)Follow-up (F)Control subjects (C)P
B vs. FB vs. CF vs. C
MGV (× 106 μm3)3.63 (3.13–4.13)4.34 (3.76–4.94)3.16 (2.34–3.97)0.0030.2890.016
GBM surface (mm2)0.51 (0.43–0.60)0.60 (0.52–0.68)0.55 (0.46–0.63)0.0040.6030.330
Nmes/glom1,222 (919–1,526)1,128 (903–1,354)768 (609–927)0.4510.0090.021
Nendo/glom1,251 (1,055–1,447)1,242 (1,035–1,448)1,003 (849–1,157)0.9010.0400.089
Npodo/glom544 (469–619)475 (422–527)580 (487–672)0.0820.5230.028
Nvmes/glom (×106 μm−3)331 (287–375)258 (227–288)245 (199–292)0.0010.0060.531
Nvendo/glom (×106 μm−3)346 (319–372)286 (267–304)331 (269–393)<0.0010.4240.156
Nvpodo/glom (×106 μm−3)198 (172–224)117 (100–134)193 (157–230)<0.0010.571<0.001
  • Data are means (95% CI). MGV, mean glomerular volume; GBM surface, surface area of glomerular basement membrane underlying podocytes (filtration surface area + mesangio-urinary surface area); Nmes/glom, mesangial cell number per glomerulus; Nendo/glom, endothelial cell number per glomerulus; Npodo/glom, podocyte number per glomerulus; Nvmes/glom, mesangial cell density per glomerulus; Nvendo/glom, endothelial cell density per glomerulus; Nvpodo/glom, podocyte density per glomerulus.