TABLE 1

Glucose Ra, Rd, Cl, and GIR and HGU and HGR (mg · kg−1 · min−1) in 18-h–fasted conscious dogs during the basal (−40 to 0) and experimental (0–300 min) periods in groups in which plasma insulin levels were kept constant, decreased, or increased

Basal periodExperimental period (min)
3060120180240300
Endogenous glucose Ra (mg · kg−1 · min−1)
 Control1.19 ± 0.171.03 ± 0.130.89 ± 0.120.82 ± 0.090.94 ± 0.110.79 ± 0.170.73 ± 0.28
 HypoINS1.23 ± 0.461.45 ± 1.072.10 ± 0.752.08 ± 0.332.52 ± 0.232.73 ± 0.22*†2.96 ± 0.17*
 HyperINS0.57 ± 0.490.07 ± 0.66−0.68 ± 0.93−0.38 ± 0.89−0.94 ± 0.92−0.45 ± 0.870.13 ± 1.26
Glucose Rd (mg · kg−1 · min−1)
 Control3.24 ± 0.293.44 ± 0.453.39 ± 0.383.36 ± 0.363.53 ± 0.443.37 ± 0.403.21 ± 0.42
 HypoINS3.15 ± 0.232.98 ± 0.652.95 ± 0.362.77 ± 0.593.03 ± 0.672.83 ± 0.662.98 ± 0.68
 HyperINS2.48 ± 0.423.49 ± 0.874.66 ± 1.425.58 ± 1.727.02 ± 2.349.25 ± 2.55*†11.85 ± 3.61*†
Glucose Cl (ml · kg−1 · min−1)
 Control3.08 ± 0.293.32 ± 0.473.28 ± 0.403.19 ± 0.363.30 ± 0.443.14 ± 0.412.97 ± 0.43
 HypoINS2.92 ± 0.222.10 ± 0.762.79 ± 0.441.97 ± 0.392.10 ± 0.261.91 ± 0.321.90 ± 0.30
 HyperINS2.35 ± 0.403.45 ± 0.884.55 ± 1.385.52 ± 1.656.97 ± 2.3*8.73 ± 2.36*†11.14 ± 3.42*†
GIR (mg · kg−1 · min−1)
 Control1.94 ± 0.322.45 ± 0.302.48 ± 0.462.62 ± 0.432.62 ± 0.442.60 ± 0.392.54 ± 0.60
 HypoINS2.33 ± 0.392.08 ± 0.691.31 ± 0.470.86 ± 0.29*0.11 ± 0.10*0.00 ± 0.00*0.00 ± 0.00*
 HyperINS1.73 ± 0.263.47 ± 0.725.55 ± 1.07*†6.77 ± 1.35*†9.87 ± 1.69*†11.05 ± 1.72*†12.36 ± 1.87*†
HGU (mg · kg−1 · min−1)
 Control0.95 ± 0.091.20 ± 0.300.81 ± 0.151.42 ± 0.341.37 ± 0.261.14 ± 0.311.12 ± 0.41
 HypoINS1.15 ± 0.220.04 ± 0.660.65 ± 0.480.88 ± 0.190.35 ± 0.26†0.24 ± 0.26*†0.26 ± 0.23*†
 HyperINS0.76 ± 0.161.14 ± 0.151.12 ± 0.231.40 ± 0.29*1.35 ± 0.24*1.72 ± 0.19*1.88 ± 0.30*
HGR (mg · kg−1 · min−1)
 Control1.23 ± 0.210.98 ± 0.300.39 ± 0.20*0.79 ± 0.210.85 ± 0.220.75 ± 0.170.84 ± 0.31
 HypoINS0.98 ± 0.470.40 ± 0.841.15 ± 0.551.64 ± 0.26†1.43 ± 0.252.24 ± 0.28*†2.28 ± 0.26*†
 HyperINS0.42 ± 0.19†0.34 ± 0.29−0.21 ± 0.250.21 ± 0.19†−0.05 ± 0.38†0.37 ± 0.510.07 ± 0.39†
  • Values are mean ± SE; n = 6; Clr, clearance; GIR, glucose infusion rate;

  • * P < 0.05 vs. basal values;

  • P < 0.05 vs. control group.