TABLE 4

Arterial blood β-OHB level (μmol/l) and NHB (μmol · kg−1 · min−1) in 18-h–fasted conscious dogs during the basal (−40 to 0 min) and experimental (0–300 min) periods in groups in which plasma insulin levels were kept constant, decreased, or increased

Basal periodExperimental period (min)
3060120180240300
Blood β-OHB level (μmol/l)
 Control35 ± 1036 ± 1832 ± 1733 ± 1728 ± 1826 ± 1328 ± 14
 HypoINS32 ± 934 ± 1737 ± 1941 ± 2167 ± 3186 ± 30*†120 ± 33*†
 HyperINS33 ± 1018 ± 109 ± 4*5 ± 2*3 ± 1*3 ± 1*3 ± 1*
Net heptaic β-OHB balance (μmol · kg−1 · min−1)
 Control1.8 ± 0.51.6 ± 0.81.4 ± 0.81.3 ± 0.61.3 ± 0.71.2 ± 0.61.3 ± 0.6
 HypoINS1.0 ± 0.31.1 ± 0.51.2 ± 0.51.4 ± 0.62.0 ± 0.82.8 ± 1.0*3.5 ± 1.2*†
 HyperINS1.2 ± 0.40.7 ± 0.40.1 ± 0.1*0.1 ± 0.1*0.1 ± 0.1*0.3 ± 0.3*0.1 ± 0.1*
  • Values are mean ± SE; n = 5;

  • * P < 0.05 vs. basal values;

  • P < 0.05 vs. control group.