TABLE 1

Biochemical and metabolic parameters for all animals at week 12

ControlControl plus ACEIControl plus AGDiabeticDiabetic plus ACEIDiabetic plus AG
n666666
Glucose (mmol/l)5.4 ± 0.25.8 ± 0.25.6 ± 0.222.1 ± 1.7*18.4 ± 2.0*21.4 ± 1.5*
HbA1c (%)3.6 ± 0.23.3 ± 0.63.9 ± 0.210.6 ± 0.4*9.1 ± 0.7*9.7 ± 0.5*
Body weight (g)453 ± 8402 ± 17420 ± 12302 ± 15*314 ± 22*341 ± 22*
Kidney-to-body weight ratio (×10−3)6.4 ± 0.37.1 ± 0.26.6 ± 0.110.7 ± 0.4*10.0 ± 0.0*10.7 ± 0.0*
GFR (ml/min)3.2 ± 0.23.3 ± 0.23.2 ± 0.13.9 ± 0.2†3.5 ± 0.34.1 ± 0.2*
Urine volume (ml/24 h)15 ± 122 ± 225 ± 2121 ± 12*76 ± 14*107 ± 16*
Blood pressure (mmHg)133 ± 3130 ± 7140 ± 5147 ± 3129 ± 7‡144 ± 5
Serum AGEs8.7 ± 0.68.3 ± 0.67.7 ± 0.611.6 ± 0.4*8.3 ± 0.6‡8.7 ± 0.5‡
  • * P < 0.005;

  • P < 0.02 vs. appropriate control;

  • P < 0.05 vs. diabetic. AG, aminoguanidine.