Biochemical and metabolic parameters for all animals at week 12
| Control | Control plus ACEI | Control plus AG | Diabetic | Diabetic plus ACEI | Diabetic plus AG | |
|---|---|---|---|---|---|---|
| n | 6 | 6 | 6 | 6 | 6 | 6 |
| Glucose (mmol/l) | 5.4 ± 0.2 | 5.8 ± 0.2 | 5.6 ± 0.2 | 22.1 ± 1.7* | 18.4 ± 2.0* | 21.4 ± 1.5* |
| HbA1c (%) | 3.6 ± 0.2 | 3.3 ± 0.6 | 3.9 ± 0.2 | 10.6 ± 0.4* | 9.1 ± 0.7* | 9.7 ± 0.5* |
| Body weight (g) | 453 ± 8 | 402 ± 17 | 420 ± 12 | 302 ± 15* | 314 ± 22* | 341 ± 22* |
| Kidney-to-body weight ratio (×10−3) | 6.4 ± 0.3 | 7.1 ± 0.2 | 6.6 ± 0.1 | 10.7 ± 0.4* | 10.0 ± 0.0* | 10.7 ± 0.0* |
| GFR (ml/min) | 3.2 ± 0.2 | 3.3 ± 0.2 | 3.2 ± 0.1 | 3.9 ± 0.2† | 3.5 ± 0.3 | 4.1 ± 0.2* |
| Urine volume (ml/24 h) | 15 ± 1 | 22 ± 2 | 25 ± 2 | 121 ± 12* | 76 ± 14* | 107 ± 16* |
| Blood pressure (mmHg) | 133 ± 3 | 130 ± 7 | 140 ± 5 | 147 ± 3 | 129 ± 7‡ | 144 ± 5 |
| Serum AGEs | 8.7 ± 0.6 | 8.3 ± 0.6 | 7.7 ± 0.6 | 11.6 ± 0.4* | 8.3 ± 0.6‡ | 8.7 ± 0.5‡ |
* P < 0.005;
† P < 0.02 vs. appropriate control;
‡ P < 0.05 vs. diabetic. AG, aminoguanidine.