TABLE 1

Identification of IL4R SNPs used and pairwise LD

SNPAmino acid variationIL4R SNP position in X52425.1IL4R SNP position in AC004525.1SNP
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1I50V398A>G94272T>C1.000.370.370.330.520.361.00
2N142N676C>T92548A>G0.35−1.00−1.00−1.000.410.381.00
3E375A1374A>C76608T>G0.16−0.151.001.000.971.00−1.00
4L389L1417G>T76565C>A0.16−0.151.001.000.971.00−1.00
5C406R1466T>C76516A>G0.13−0.140.960.961.001.00−1.00
6S478P1682T>C76300A>G0.260.280.790.790.781.001.00
7Q551R1902A>G76080T>C0.210.230.720.720.690.881.00
8S761P2531T>C75451A>G0.100.29−0.04−0.04−0.040.200.18
  • Information identifying the IL4R SNPs is presented in the first four columns of the table. Each SNP is described by its position in the GenBank cDNA reference accession sequence X52425.1, and in the reference genomic sequence for chromosome 16 BAC clone AC004525.1 (these two sequences are antiparallel). The amino acid variation numbering refers to that of the mature IL4R protein (4,11). The remaining eight columns present two measures of linkage disequilibrium (LD) between all pairs of IL4R SNPs used in this study. D’ values are shown in the upper-right triangle; Δ values in the lower-left triangle. Bold text indicates LD measures whose absolute values are near 1.0, indicating “complete” or “absolute” pairwise LD.