TABLE 2

TDT analysis of individual IL4R SNPs

SNPAll families (n = 282)Either/both sib DR3/4 (n = 135)Neither sib DR3/4 (n = 147)
Number of informative transmission events% Transmission of reference allele to affectedsMcNemar χ2 statisticPNumber of informative transmission events% Transmission of reference allele to affectedsMcNemar χ2 statisticPNumber of informative transmission events% Transmission of reference allele to affectedsMcNemar χ2 statisticP
156447.3%1.600.2125651.6%0.250.6230853.6%1.570.21
218854.8%1.720.198852.3%0.180.6710057.0%1.960.16
321656.0%3.130.0810453.8%0.620.4311258.0%2.890.09
421656.0%3.130.0810453.8%0.620.4311258.0%2.890.09
521455.1%2.260.1310453.8%0.620.4311056.4%1.780.18
631455.4%3.680.0613852.2%0.260.6117658.0%4.450.03
736854.1%2.450.1217052.9%0.590.4419855.1%2.020.16
82450.0%0.001.001442.9%0.290.591060.0%0.400.53
  • The table lists the observed transmissions of the reference allele (as defined in Table 1) at each of the eight IL4R SNP loci individually. The TDT analysis was performed on the complete HBDI cohort and after stratification for HLA-DR3/4 status, as described in the text. The number of informative transmissions for each SNP and the percent transmission are listed, as are the associated McNemar χ2 statistic and the significance level. P values are shown before adjustment.