TABLE 3

TDT analysis of IL4R haplotypes

Haplotype IDHaplotypeAll familiesEither/both sib DR3/4Neither sib DR3/4
Number of informative transmission events% transmittedOR95% CINumber of informative transmission events% transmittedOR95% CINumber of informative transmission events% transmittedOR95% CI
H-11111111155052%1.090.92–1.3026952%1.080.85–1.3828153%1.110.86–1.40
H-22111111149851%1.060.90–1.2522650%1.010.80–1.2827252%1.100.86–1.42
H-32122222112239%*0.630.44–0.896144%0.800.50–1.276233%†0.490.28–0.81
H-4221111119347%0.890.61–1.305045%0.810.47–1.364350%0.990.56–1.71
H-5112222218649%0.950.59–1.503740%0.680.30–1.424955%1.240.67–2.36
H-6221112217744%0.780.45–1.242752%1.070.49–2.405040%0.650.31–1.23
H-7111111217757%1.330.90–2.064355%1.230.71–2.203360%1.480.75–3.19
H-8211111212743%0.750.38–1.601238%0.610.18–2.221547%0.880.38–3.09
H-9221112221645%0.830.25–2.681050%1.00—‡638%0.60—‡
  • Each haplotype is listed by the ordered set of alleles present at each of the eight IL4R SNPs. A “1” denotes the presence of the reference allele, and a “2” indicates the presence of the variant allele for each SNP, as described in Table 1. Haplotypes are also given arbitrary haplotype ID numbers (H-1 through -9). The table shows only haplotypes that were observed in at least 15 effective transmission events in the affected children (representing 1,546/1,658 = 93% of observed haplotypes in informative transmission events). For each haplotype, percent transmitted is the ratio of actual transmissions to possible transmissions to affected children of informative parents. The ORs compare actual with Mendelian segregation ratios. The 95% CI column lists the upper and lower bounds of the 95% CI of the OR, calculated based on the number of families (not shown) informative for that haplotype. P values are based on permutation.

  • * Significant after adjustment at P = 0.021;

  • significant after adjustment at P = 0.015;

  • CIs are not reported in instances where 10 or fewer families were informative for the haplotype.