TABLE 1

LD estimates (D′ above the diagonal) and associated P values (below the diagonal) between pairs of SNPs in KCNJ10 in the case-control study

SNP1SNP3SNP4SNP5SNP8
SNP1 (0.67)1.00−0.91−0.19−0.65
SNP3 (0.95)<0.01−1.001.00−1.00
SNP4 (0.86)<0.010.04−0.87−0.81
SNP5 (0.61)0.07<0.01<0.01−1.00
SNP8 (0.75)<0.01<0.01<0.01<0.01
  • D′ represents the extent of LD between alleles at each locus, expressed as a proportion of the maximum possible given the direction of association. A positive D′ number represents an association between the more frequent alleles at each locus, whereas a negative number represents an association between the more frequent allele at one locus and the less frequent allele at the other locus. The P value for the null hypothesis of no LD is also shown. SNP1 and SNP2 (not listed here) are in complete LD; SNP6 and SNP7 were rare (0.03) and their D′ could not be reliably assessed in relation to the other markers. The numbers in parenthesis represent the frequency of the most common allele of that particular SNP.