TABLE 2

Genotypic distribution for KCNJ10 polymorphism and odds ratio (OR) with 95% CI for diabetes in participants in the case-control study and genome-wide linkage studies

StatusGenotypeDominant modelRecessive modelAdditive modelOverall P
111222OR (95 % CI)POR (95 % CI)POR (95 % CI)P
All participants in case-control study
SNP1Nondiabetic71 (53)51 (38)13 (10)
Diabetic65 (44)60 (41)22 (15)0.61 (0.29–1.26)0.2070.72 (0.45–1.14)0.1900.75 (0.53–1.05)0.0970.263
SNP3Nondiabetic134 (93)10 (7)0 (0)
Diabetic135 (91)13 (9)0 (0)0.78 (0.33–1.82)0.6660.77 (0.38–1.83)0.5610.666
SNP4Nondiabetic113 (79)26 (18)4 (3)
Diabetic115 (79)27 (18)3 (2)1.36 (0.30–6.21)0.7221.02 (0.58–1.80)1.0001.05 (0.64–1.70)0.8560.967
SNP5Nondiabetic58 (40)59 (41)27 (19)
Diabetic60 (40)73 (49)17 (11)1.81 (0.94–3.48)0.1010.99 (0.62–1.57)1.0001.16 (0.83–1.61)0.3810.163
SNP8Nondiabetic74 (52)56 (39)12 (8)
Diabetic83 (56)57 (39)8 (5)1.62 (0.64–4.08)0.3581.17 (0.74–1.86)0.5561.20 (0.83–1.74)0.3380.563
Participants in case-control study and in genome-wide linkage study
SNP1Nondiabetic23 (55)17 (41)2 (5)
Diabetic17 (35)24 (50)8 (16)0.26 (0.05–1.28)0.1000.44 (0.19–1.02)0.0610.47 (0.24–0.92)0.0270.088
SNP3Nondiabetic39 (89)5 (11)0 (0)
Diabetic45 (90)5 (10)0 (0)1.15 (0.31–4.29)1.0001.15 (0.31–4.28)0.8311.000
SNP4Nondiabetic35 (80)9 (20)0 (0)
Diabetic35 (71)12 (25)2 (4)0.64 (0.25–1.68)0.4720.59 (0.25–1.41)0.2360.500
SNP5Nondiabetic15 (34)18 (41)11 (25)
Diabetic20 (40)27 (54)3 (6)5.22 (1.35–20.2)0.0181.29 (0.56–2.99)0.6701.71 (0.98–3.15)0.0830.035
SNP8Nondiabetic21 (48)19 (43)4 (9)
Diabetic29 (60)18 (38)1 (2)4.70 (0.5–43.8)0.1891.67 (0.73–3.82)0.2951.75 (0.87–3.53)0.1190.242
All participants in genome-wide linkage study
SNP1Nondiabetic216 (50)182 (42)35 (8)
Diabetic250 (40)296 (48)76 (12)0.62 (0.39–0.99)0.0430.75 (0.55–1.02)0.0710.76 (0.64–0.95)0.0180.048
SNP5Nondiabetic169 (40)195 (47)55 (13)
Diabetic226 (37)296 (49)86 (14)1.05 (0.66–1.67)0.8420.88 (0.65–1.20)0.4360.95 (0.75–1.20)0.6690.663
  • Data are n (%) unless otherwise indicated. For all SNPs the more common allele is coded as “1” and the less common allele is coded as “2.” For the “dominant” model ORs are calculated comparing those homozygous or heterozygous for the common allele (11 or 12) with the odds for those homozygous for the less common allele (22). Similarly, the “recessive” model compares those homozygous for the common allele (11) with the others (12 or 22). In the additive model, the OR is calculated for each copy of the common allele. In the case-control study, P values are calculated by Fisher’s exact test, except for the additive model, for which the P value is calculated by the χ2 test. For the subjects in the genome-wide linkage study, the ORs and P values are calculated by generalized estimating equations that adjust for age, sex, birth year, and ethnicity and that account for family membership (sibship). The dominant model is not analyzed in instances where there are too few individuals homozygous for the rare allele to obtain reliable estimates. The genotypes are presented as total numbers and their percent in parenthesis.