TABLE 4

Hazards ratios* (95% CI) of cardiovascular events and non-CHD mortality associated quartiles of baseline HRV indexes according to diabetes status: 8 years of follow-up of the ARIC cohort

Quartiles of HRVIncident CHDIncident MIFatal CHDNon-CHD death
Diabetic subjects (n = 1,275)(n = 161)(n = 94)(n = 31)(n = 142)
 HF
  Q4 (Highest)1.001.001.001.00
  Q30.90 (0.50–1.59)0.92 (0.42–1.99)0.42 (0.10–1.78)0.64 (0.37–1.12)
  Q21.07 (0.62–1.86)1.15 (0.55–2.39)0.59 (0.16–2.21)0.71 (0.41–1.25)
  Q1 (Lowest)1.87 (1.15–3.03)2.27 (1.20–4.30)1.29 (0.45–3.69)1.23 (0.77–1.97)
 LF
  Q4 (Highest)1.001.001.001.00
  Q30.75 (0.42–1.35)0.53 (0.24–1.17)1.26 (0.21–7.58)0.90 (0.48–1.69)
  Q20.98 (0.58–1.67)0.82 (0.41–1.63)1.60 (0.32–8.08)0.88 (0.49–1.58)
  Q1 (Lowest)1.65 (1.02–2.68)1.72 (0.94–3.13)3.49 (0.79–15.50)1.57 (0.92–2.69)
 2-min SDNN
  Q4 (Highest)1.001.001.001.00
  Q30.85 (0.47–1.55)0.85 (0.38–1.91)1.54 (0.28–8.47)0.93 (0.48–1.79)
  Q21.00 (0.58–1.75)1.09 (0.51–2.32)1.72 (0.34–8.65)1.27 (0.69–2.37)
  Q1 (Lowest)1.75 (1.04–2.96)2.28 (1.13–1.91)2.54 (0.54–11.98)1.48 (0.81–2.69)
 MSSD
  Q4 (Highest)1.001.001.001.00
  Q31.16 (0.65–2.05)1.25 (0.61–2.58)1.66 (0.41–6.69)1.01 (0.56–1.82)
  Q20.89 (0.48–1.66)0.77 (0.33–1.77)0.21 (0.02–2.10)1.06 (0.58–1.95)
  Q1 (Lowest)1.78 (1.03–3.10)1.93 (0.94–3.97)1.64 (0.42–6.43)1.35 (0.76–2.43)
Nondiabetic subjects (n = 10,372)(n = 474)(n = 252)(n = 51)(n = 480)
 HF
  Q4 (Highest)1.001.001.001.00
  Q31.03 (0.79–1.33)1.05 (0.74–1.47)0.83 (0.35–1.99)1.34 (1.02–1.76)
  Q20.83 (0.63–1.08)0.86 (0.60–1.22)1.16 (0.53–2.51)1.12 (0.85–1.48)
  Q1 (Lowest)0.93 (0.71–1.20)0.71 (0.49–1.03)1.00 (0.45–2.22)1.38 (1.05–1.80)
 LF
  Q4 (Highest)1.001.001.001.00
  Q31.07 (0.83–1.38)1.02 (0.72–1.44)0.88 (0.34–2.28)0.94 (0.71–1.25)
  Q21.12 (0.87–1.44)1.03 (0.72–1.45)1.50 (0.65–3.49)1.07 (0.82–1.40)
  Q1 (Lowest)1.01 (0.78–1.32)0.90 (0.62–1.29)1.92 (0.85–4.31)1.33 (1.03–1.73)
 2-min SDNN
  Q4 (Highest)1.001.001.001.00
  Q31.02 (0.78–1.31)1.08 (0.75–1.54)1.50 (0.61–3.68)1.05 (0.83–1.37)
  Q21.05 (0.80–1.36)1.15 (0.80–1.66)1.48 (0.59–3.68)0.91 (0.69–1.20)
  Q1 (Lowest)1.26 (0.96–1.67)1.38 (0.94–2.03)2.29 (0.93–5.62)1.12 (0.85–1.48)
 MSSD
  Q4 (Highest)1.001.001.001.00
  Q30.82 (0.62–1.07)0.63 (0.43–0.91)0.73 (0.31–1.72)1.03 (0.79–1.35)
  Q20.87 (0.67–1.14)0.85 (0.60–1.21)1.75 (0.32–1.74)0.91 (0.69–1.19)
  Q1 (Lowest)1.09 (0.81–1.46)0.89 (0.60–1.32)1.13 (0.48–2.68)0.97 (0.72–1.31)
  • *

    * All models were fitted with quartile of HRV, diabetes status, and HRV-diabetes interaction terms as dependent variables, simultaneously adjusted for baseline age, sex, ethnicity-center, cigarette smoking status, and mean heart rate.