TABLE 5

Multivariable adjusted* proportional hazard ratios (95% CI) of cardiovascular events and non-CHD mortality comparing the lowest and upper three quartiles of HRV indexes, according to diabetes status: 8 years of follow-up of the ARIC study

Lowest quartile of frequency domain HRV indexes
Lowest quartile of time domain HRV indexes
HFLF2-min SDNNMSSD
Diabetic subjects (n = 1,275)
 Incident CHD (n = 161)1.55 (1.13–2.13)1.47 (1.07–2.02)1.49 (1.07–2.07)1.51 (1.08–2.11)
 Incident MI (n = 94)1.75 (1.15–2.65)1.79 (1.18–2.72)1.80 (1.16–2.77)1.59 (1.02–2.47)
 Fatal CHD (n = 31)1.61 (0.75–3.46)1.94 (0.90–4.18)1.31 (0.59–2.90)1.65 (0.71–3.80)
 Non-CHD death (n = 42)1.37 (0.97–1.94)1.58 (1.12–2.23)1.20 (0.84–1.71)1.08 (0.75–1.55)
Nondiabetic subjects (n = 10,379)
 Incident CHD (n = 474)0.95 (0.78–1.17)0.86 (0.69–1.08)1.17 (0.94–1.45)1.22 (0.98–1.52)
 Incident MI (n = 252)0.74 (0.54–1.00)0.81 (0.60–1.10)1.22 (0.91–1.64)1.11 (0.81–1.51)
 Fatal CHD (n = 51)0.83 (0.44–1.57)1.50 (0.84–2.70)1.52 (0.82–2.80)1.30 (0.68–2.46)
 Non-CHD death (n = 481)1.21 (0.99–1.48)1.35 (1.11–1.64)1.14 (0.93–1.41)1.03 (0.82–1.29)
  • *

    * Adjusted for baseline age, sex, ethnicity-center, cigarette smoking status, heart rate, BMI, fasting glucose, triglycerides, HDL cholesterol, and hypertension.