TABLE 2

Effect of the genetic polymorphisms on BMI and IR indices in the SGA and AGA groups

SGA (n = 171)
AGA (n = 233)
P value*
TNF-α/G-308AGG (n = 125)A+ (n = 46)P valueGG (n = 172)A+ (n = 61)P value
 BMI (kg/m2)22.1 (5.6)22.0 (4.2)0.2022.0 (3.4)23.2 (5.0)0.070.74
 Fasting insulin (pmol/l)32.4 (26.4)43.2 (31.2)0.00829.4 (13.2)31.2 (13.8)0.770.03
 Insulin AUC (pmol · min−1 · 10−3)31.8 (18.6)40.2 (28.8)0.0926.4 (13.8)27.6 (13.8)0.500.44
 Insulin/glucose ratio6.1 (4.5)8.2 (5.7)0.035.8 (2.6)5.9 (2.6)0.670.01
ADRB3/G+250CGG (n = 152)C+ (n = 19)P valueGG (n = 207)C+ (n = 26)P value
 BMI (kg/m2)22.4 (4.0)22.4 (3.1)0.9922.4 (4.3)21.4 (2.6)0.340.42
 Fasting insulin (pmol/l)33.6 (24.0)48.6 (50.4)0.0330.0 (13.2)27.6 (12.6)0.400.01
 Insulin AUC (pmol · min−1 · 10−3)31.8 (20.4)45.6 (28.2)0.0727.6 (13.8)22.2 (12.0)0.050.005
 Insulin/glucose ratio6.4 (4.0)9.2 (9.2)0.025.9 (2.6)5.6 (2.8)0.580.01
PPAR-γ/Pro12AlaPro/Pro (n = 133)Ala+ (n = 38)P valuePro/Pro (n = 179)Ala+ (n = 54)P value
 BMI (kg/m2)22.5 (4.0)22.1 (3.2)0.5422.4 (4.2)22.4 (3.7)0.990.65
 Fasting insulin (pmol/l)33.6 (28.2)39.0 (27.0)0.1230.0 (13.8)28.8 (11.4)0.770.03
 Insulin AUC (pmol · min−1 · 10−3)31.8 (21.6)38.4 (22.8)0.0527.0 (13.2)26.4 (15.6)0.540.05
 Insulin/glucose ratio6.4 (4.9)7.6 (5.1)0.015.9 (2.8)5.7 (2.2)0.480.04
  • Data are expressed as means (SD). Tests were performed after adjustment for sex and age for BMI, and for sex, age, BMI, family history of type 2 diabetes, smoking, and oral contraception for IR indices.

  • *

    * For the tests of the statistical interaction between genetic effect (gene polymorphism) and size at birth (SGA versus AGA) for each parameter after adjustment for confounding factors.

  • Within each group for the tests of the statistical comparison of each parameter between the carriers and the noncarriers of the genetic polymorphisms.