TABLE 1

Characteristics of lean and obese Zucker rats

LeanObese
Body weight (g)322 ± 4445 ± 5*
Epididymal fat pad (g)1.3 ± 0.14.4 ± 0.2*
Calf muscle mass (g)1.58 ± 0.031.16 ± 0.03*
Plasma insulin (pmol/l)182 ± 214158 ± 491*
Blood glucose (mmol/l)4.8 ± 0.211.7 ± 0.6*
Blood pressure (mmHg)107 ± 2107 ± 1
Heart rate (beats/min)335 ± 9329 ± 6
Femoral blood flow (ml/min)0.69 ± 0.050.69 ± 0.05
Vascular resistance (RU)164 ± 10172 ± 14
  • Data are means ± SE for n = 14–17 rats in each group.

  • *

    * Significantly different (P < 0.05) from lean Zucker rats. Epididymal fat pad and calf muscles were removed from rats at the completion of the experiment. All other values were measured at the commencement of saline or insulin infusion. Calf muscle mass includes soleus, plantaris, and whole gastrocnemius.