TABLE 1

Islet transplants expressing IDO result in longer survival time

Islet treatmentnDays of graft survivalMedianMean survival timeSD
Control (i.e, no STZ, no transplant)2917, 19, 20, 24, 25, 26 (×3), 28 (×4), 29, 29, 30, 31 (×5), 32, 32, 33, 33, 34, 36, 39, 39, 4030.029.55.5
Neg (uninfected)919, 20, 26, 28, 33, 33, 35, 35, 5933.032.011.8
Ad-LacZ107, 14, 17, 21, 21, 29, 32, 35, 49, 6125.028.616.5
Ad-IDO1524, 30, 32, 37, 37, 40 (×4), 45, 46, 50, 63, 83, 18440.0*52.739.0
  • STZ-treated NODscid recipients were transplanted with untreated or adenovirus-infected islets. Diabetes was adoptively transferred by injection of 2 × 107 spleen cells pooled from naturally diabetic NOD females. Graft survival times are expressed in days postchallenge.

  • *

    * Ad-IDO transplant survival curves (Kaplan-Meier analysis) were significantly different than control (no transplant, P < 0.0001), Neg (transplanted with uninfected islets, P = 0.01) and Ad-LacZ–treated grafts (P = 0.02). Note that even when removing the longest surviving transplant (184 days), the difference in survival curves remains statistically significant (P = 0.04).