TABLE 1

Fasting and meal-related results

NN2211PlaceboP
Fasting values
    plasma glucose (mmol/l)6.9 ± 1.08.1 ± 1.0<0.01
    insulin secretory rate (pmol/min)179 ± 70163 ± 660.03
    glucagon (pmol/l)19 ± 420 ± 4NS
Homeostasis model assessment
    HOMA-B0.56 ± 0.160.36 ± 0.12<0.001
    HOMA-S3.0 ± 1.33.1 ± 1.7NS
Meal-related AUC1130-1530h
    plasma glucose (mmol · l−1 · h−1)30.6 ± 2.439.9 ± 7.3<0.001
    plasma glucose (mmol · l−1 · h−1) increment7.0 ± 2.69.6 ± 4.50.04
    insulin secretory rate (nmol)118 ± 32106 ± 27NS
    insulin secretory rate (nmol) increment65 ± 2245 ± 110.03
    glucagon (pmol · l−1 · h−1)77 ± 1882 ± 170.04
    glucagon (pmol · l−1 · h−1) increment6 ± 106 ± 10NS
    3-OMG (mg · l−1 · h−1)400 ± 84440 ± 700.02
  • Mean fasting values and HOMA were calculated from samples obtained at 7 h and 8 h. The meal response was calculated as integrated AUC in absolute values and as increments relative to premeal values (mean of 1115 h and 1130 h) for glucose, ISR, glucagon, and 3-OMG. NS, not significant.