TABLE 2

Deconvolution and regularity analysis

NN2211PlaceboP
Deconvolution analysis—baseline period
    insulin secretory burst mass (pmol · l−1 · pulse−1)24 ± 1422 ± 14NS
    insulin secretory burst amplitude (pmol · l−1 · min−1)10.3 ± 5.59.1 ± 5.3NS
    basal insulin secretion (pmol · l−1 · min−1)8.1 ± 3.36.5 ± 3.00.04
    interpulse interval (minutes)5.8 ± 0.75.8 ± 1.0NS
Baseline insulin pulse regularity
    ApEn (m = 1, r = 0.2 × SD)1.41 ± 0.071.38 ± 0.11NS
    ApEn (m = 1, r = 1.0 × SD)0.65 ± 0.070.65 ± 0.08NS
Glucose pulse entrainment
    spectral power7.3 ± 3.94.9 ± 2.3NS (0.095)
    autocorrelation coefficient0.16 ± 0.130.11 ± 0.17NS (0.066)
    ApEn (m = 1, r = 0.2 × SD)1.36 ± 0.071.36 ± 0.05NS
    ApEn (m = 1, r = 1.0 × SD)0.64 ± 0.080.65 ± 0.07NS
  • Results from time series analysis of insulin concentration time series obtained during baseline conditions and during glucose pulse entrainment with 6 mg/kg every 10 min. NS, not significant, if 0.1 > P > 0.05 the value is given in brackets.