TABLE 2

Glomerular structural characteristics of nondiabetic control subjects and patients with long-standing type 1 diabetes

Control subjectsAER categories
P
NormoalbuminuriaMicroalbuminuriaProteinuria
GBM width (nm)332 ± 46465 ± 100602 ± 157700 ± 141<0.0001
Vv(Mes/glom)0.20 ± 0.030.28 ± 0.070.34 ± 0.090.50 ± 0.12<0.0001
Vv(MM/glom)0.09 ± 0.020.16 ± 0.050.19 ± 0.080.31 ± 0.09<0.0001
Vv(MC/glom)0.08 ± 0.020.09 ± 0.020.10 ± 0.030.14 ± 0.06<0.0001
Vv[MM/(MM+MC)]0.51 ± 0.080.63 ± 0.070.64 ± 0.110.70 ± 0.10<0.0001
Sv(PGBM/glom) (μm2/μm3)0.13 ± 0.020.11 ± 0.020.10 ± 0.030.06 ± 0.03<0.0001
MESNA0.39 ± 0.320.66 ± 0.481.12 ± 0.61<0.0001
  • Data are means ± SD. NA, not applicable in nondiabetic control subjects because MES factors for diabetes duration.