TABLE 3

Characteristics of GK rats after 6 weeks of high-fat diet or regular diet and insulin treatment

Nontreated
Insulin-treated
GK-RDGK-HFDGK-RDGK-HFD
Body weight (g)296 ± 9330 ± 6*310 ± 5336 ± 8
Epididymal fat (g)3.8 ± 0.37.3 ± 0.3*3.4 ± 0.17.4 ± 0.4*
Plasma TGs (mg/dl)54.0 ± 6.7135.7 ± 20.2*43.0 ± 2.999.7 ± 14.0*
Plasma FAs (mM)0.16 ± 0.020.42 ± 0.07*0.14 ± 0.030.18 ± 0.03
Fasting plasma glucose (mg/dl)169.5 ± 2.6224.3 ± 5.9*129.8 ± 27.6138.5 ± 15.9
Plasma leptin (ng/ml)7.4 ± 0.416.7 ± 0.77.0 ± 0.518.5 ± 1.5
  • Data are means ± SE. HFD, high-fat diet, RD, regular diet.

  • *

    * P < 0.05;

  • P < 0.05 (insulin-treated vs. untreated within diet treatment);

  • P < 0.0001 (HFD vs. RD within treatment). n = 4–11 replicate measurements in each group.