TABLE 2

Mean (±SE) plasma glucose concentrations (mg/dl*) during hyperinsulinemic stepped hypoglycemic clamps on the morning and, after an additional 2 h of hypoglycemia (50 mg/dl), the afternoon of day 1 and on the morning of day 2 in nondiabetic subjects (n = 15) and patients with type 2 diabetes treated with OHA (n = 7) or with insulin (n = 6)

Time (min)
−30−150306090120150180210240270300
Nondiabetic subjects
 Day 188 ± 488 ± 382 ± 279 ± 581 ± 274 ± 277 ± 166 ± 268 ± 352 ± 356 ± 146 ± 244 ± 2
 Day 286 ± 389 ± 188 ± 380 ± 379 ± 575 ± 277 ± 263 ± 264 ± 255 ± 253 ± 246 ± 142 ± 2
Type 2 diabetic patients
 OHA Rx
  Day 1161 ± 25161 ± 25146 ± 22120 ± 1396 ± 1084 ± 470 ± 365 ± 267 ± 454 ± 254 ± 250 ± 244 ± 12
  Day 292 ± 492 ± 388 ± 388 ± 183 ± 474 ± 274 ± 462 ± 264 ± 153 ± 353 ± 245 ± 345 ± 1
 Insulin Rx
  Day 1136 ± 10142 ± 10116 ± 13101 ± 1284 ± 579 ± 474 ± 466 ± 568 ± 355 ± 255 ± 354 ± 546 ± 3
  Day 2108 ± 12103 ± 11106 ± 12103 ± 1297 ± 677 ± 474 ± 468 ± 367 ± 561 ± 454 ± 350 ± 247 ± 2
  • *

    * Multiply mg/dl by 0.0551 to convert to mmol/l.