TABLE 3

Mean (±SE) plasma insulin concentrations (μU/ml*) during hyperinsulinemic stepped hypoglycemic clamps on the morning and, after an additional 2 h of hypoglycemia (50 mg/dl), the afternoon of day 1 and on the morning of day 2 in nondiabetic subjects (n = 15) and patients with type 2 diabetes treated with OHA (n = 7) or insulin (n = 6)

Time (min)
P
−120−300306090120150180210240270300
Nondiabetic subjects
 Day 110 ± 253 ± 356 ± 696 ± 11117 ± 12106 ± 13120 ± 12123 ± 12126 ± 8127 ± 9121 ± 12137 ± 8141 ± 8
 Day 26 ± 456 ± 460 ± 5108 ± 7113 ± 6121 ± 7120 ± 6123 ± 9116 ± 11130 ± 10120 ± 10118 ± 8128 ± 70.1920
Type 2 diabetic patients
 OHA Rx
  Day 116 ± 495 ± 21138 ± 32210 ± 51264 ± 61248 ± 78267 ± 83239 ± 50222 ± 54210 ± 47204 ± 37203 ± 60215 ± 31
  Day 240 ± 1357 ± 896 ± 23110 ± 22114 ± 29138 ± 25145 ± 26154 ± 26162 ± 27148 ± 29159 ± 27173 ± 27227 ± 510.4441
 Insulin Rx
  Day 117 ± 553 ± 1495 ± 22264 ± 27344 ± 52311 ± 54310 ± 50302 ± 45292 ± 44302 ± 46288 ± 42313 ± 49296 ± 68
  Day 224 ± 441 ± 1251 ± 11211 ± 32270 ± 40288 ± 46305 ± 45306 ± 54307 ± 50300 ± 45299 ± 48329 ± 52317 ± 520.9253
  • *

    * Multiply μU/ml by 6.0 to convert to pmol/l;

  • P = 0.0175 versus nondiabetic;

  • P = 0.0016 versus nondiabetic.