TABLE 4

Mean (±SE) plasma glucagon concentrations (pg/ml*) during hyperinsulinemic stepped hypoglycemic clamps on the morning and, after an additional 2 h of hypoglycemia (50 mg/dl), the afternoon of day 1 and on the morning of day 2 in nondiabetic subjects (n = 15) and patients with type 2 diabetes treated with OHA (n = 7) or insulin (n = 6)

Time (min)
P
−30−150306090120150180210240270300
Nondiabetic subjects
 Day 172 ± 1259 ± 567 ± 1159 ± 1060 ± 1062 ± 962 ± 1171 ± 1470 ± 268 ± 1088 ± 15105 ± 1893 ± 15
 Day 254 ± 655 ± 650 ± 549 ± 547 ± 548 ± 545 ± 551 ± 446 ± 646 ± 663 ± 4369 ± 1273 ± 100.0249
Type 2 diabetic subjects
 OHA Rx
  Day 162 ± 857 ± 459 ± 648 ± 456 ± 753 ± 765 ± 1169 ± 1072 ± 1378 ± 1190 ± 2290 ± 2298 ± 16
  Day 247 ± 755 ± 948 ± 642 ± 639 ± 539 ± 941 ± 839 ± 548 ± 1342 ± 655 ± 762 ± 952 ± 160.0036
 Insulin Rx
  Day 149 ± 248 ± 346 ± 443 ± 444 ± 545 ± 448 ± 950 ± 854 ± 1053 ± 756 ± 952 ± 556 ± 5
  Day 244 ± 645 ± 348 ± 445 ± 537 ± 338 ± 539 ± 534 ± 333 ± 442 ± 945 ± 848 ± 951 ± 80.0821
  • *

    * Multiply pg/dl by 0.02871 to convert to pmol/l;

  • type 2 diabetic (n = 13) P = 0.0015 day 2 versus day 1;

  • day 1 P = 0.0252 versus nondiabetic.