TABLE 5

Mean (±SE) plasma epinephrine concentrations (pg/ml*) during hyperinsulinemic stepped hypoglycemic clamps on the morning and, after an additional 2 h of hypoglycemia (50 mg/dl), the afternoon of day 1 and on the morning of day 2 in nondiabetic subjects (n = 15) and patients with type 2 diabetes treated with OHA (n = 7) or insulin (n = 6)

Time (min)
P
−30−150306090120150180210240270300
Nondiabetic subjects
 Day 140 ± 1730 ± 730 ± 724 ± 538 ± 1342 ± 1045 ± 10111 ± 38147 ± 35270 ± 64353 ± 42728 ± 74830 ± 79
 Day 231 ± 737 ± 935 ± 937 ± 937 ± 734 ± 840 ± 851 ± 1369 ± 21110 ± 28227 ± 73368 ± 70587 ± 830.0001
Type 2 diabetic patients
 OHA Rx
  Day 117 ± 214 ± 215 ± 318 ± 426 ± 5156 ± 11362 ± 218410 ± 173437 ± 188686 ± 246836 ± 2661043 ± 356946 ± 203
  Day 231 ± 523 ± 523 ± 529 ± 529 ± 437 ± 962 ± 2176 ± 2976 ± 30159 ± 81156 ± 44322 ± 84439 ± 1280.0022
 Insulin Rx
  Day 122 ± 614 ± 424 ± 926 ± 917 ± 435 ± 16600 ± 20130 ± 65121 ± 41225 ± 78372 ± 98403 ± 98403 ± 158
  Day 219 ± 317 ± 220 ± 518 ± 320 ± 425 ± 524 ± 825 ± 835 ± 1158 ± 28145 ± 69195 ± 88352 ± 1510.0740
  • *

    * Multiply pg/ml by 5.458 to convert to pmol/l;

  • type 2 diabetic (n = 13) P = 0.0002 day 2 versus day 1;

  • day 1 P = 0.0082 versus nondiabetic.