TABLE 6

Mean (± SE) plasma norepinephrine concentrations (pg/ml*) during hyperinsulinemic stepped hypoglycemic clamps on the morning and, after an dditional 2 h of hypoglycemia (50 mg/dl), the afternoon of day 1 and on the morning of day 2 in nondiabetic subjects (n = 15) and patients with type 2 diabetes treated with OHA (n = 7) or insulin (n = 6)

Time (min)
P
−30−150306090120150180210240270300
Nondiabetic subjects
 Day 1202 ± 22231 ± 25242 ± 25227 ± 22248 ± 29241 ± 28238 ± 29260 ± 33282 ± 27326 ± 24334 ± 24456 ± 43501 ± 40
 Day 2213 ± 26220 ± 25250 ± 31237 ± 29249 ± 26254 ± 23237 ± 26244 ± 26245 ± 27240 ± 25316 ± 37343 ± 22448 ± 220.0106
Type 2 diabetic patients
 OHA Rx
  Day 1232 ± 11222 ± 9255 ± 12263 ± 17265 ± 22296 ± 25352 ± 53402 ± 43389 ± 59491 ± 79567 ± 90660 ± 123646 ± 106
  Day 2240 ± 23244 ± 29247 ± 30250 ± 23260 ± 14259 ± 13289 ± 22288 ± 26296 ± 25335 ± 80358 ± 60484 ± 104602 ± 1250.0441
 Insulin Rx
  Day 1182 ± 28191 ± 30193 ± 33171 ± 22193 ± 29188 ± 22202 ± 21239 ± 27234 ± 23257 ± 23345 ± 37335 ± 61465 ± 60
  Day 2192 ± 38175 ± 28171 ± 32193 ± 47182 ± 32197 ± 54193 ± 50201 ± 48205 ± 27214 ± 50238 ± 66258 ± 58339 ± 810.1434
  • *

    * Multiply pg/ml by 0.005911 to convert to nmol/l;

  • type 2 diabetic (n = 13) P = 0.0138 day 2 versus day 1;

  • day 1 P = 0.0028 versus nondiabetic.