TABLE 1

Anthropometric and fasting plasma metabolite concentrations before and after 3 months of rosiglitazone treatment

BeforeAfterP
Body weight (kg)92.3 ± 6.293.9 ± 5.70.34
BMI (kg/m2)31.1 ± 1.631.9 ± 1.70.20
Lean body mass (kg)61.3 ± 3.459.9 ± 2.50.98
Body fat (%)29.9 ± 3.633.1 ± 4.50.78
HbA1c (%)6.7 ± 0.4%7.2 ± 0.6%0.23
Plasma glucose (mmol/l)9.0 ± 0.97.9 ± 0.90.02
Insulin (pmol/l)93.6 ± 13.871.4 ± 7.80.03
C-peptide (pmol/l)0.83 ± 0.080.76 ± 0.060.19
Glucagon (ng/l)87.0 ± 9.083.2 ± 7.30.54
Total cholesterol (mmol/l)4.97 ± 0.395.43 ± 0.410.09
HDL cholesterol (mmol/l)0.88 ± 0.050.96 ± 0.050.15
LDL cholesterol (mmol/l)2.92 ± 0.343.31 ± 0.210.14
Triglycerides (mmol/l)6.31 ± 1.666.26 ± 1.340.97
Fatty acids (μmol/l)497 ± 64352 ± 550.003
Leptin (ng/ml)21.1 ± 5.718.4 ± 4.70.34
Alkaline phosphatase (units/l)72 ± 761 ± 70.007
γ-Glutamyl transpeptidase (units/l)29 ± 617 ± 30.001
  • Data are means ± SE.