TABLE 2

Diabetes and subphenotypes in the males of the RCS and parental strains

StrainNIDDM by 24 weeks (n)BW at 16 weeks (g)Insulin at 24 weeks (ng/ml)Leptin at 24 weeks (ng/ml)Food consumption at 6 weeks (g/day)
110/18 (56)37.8 ± 0.6*3.2 ± 0.5§13.8 ± 3.53.1
20/17 (0)35.2 ± 0.82.9 ± 0.5§11.2 ± 2.23.3
31/19 (5)40.9 ± 0.9*6.2 ± 1.2§10.8 ± 2.24.0
41/14 (7)39.9 ± 0.8*2.9 ± 0.2*8.2 ± 1.44.0
51/19 (5)40.0 ± 0.8*5.4 ± 1.2§8.6 ± 1.14.2
69/20 (45)40.7 ± 1.4*4.1 ± 0.7§11.3 ± 2.64.2
76/16 (38)43.5 ± 1.2*11.7 ± 2.9*9.7 ± 1.93.6
812/18 (67)45.5 ± 0.7*13.5 ± 2.4*20.3 ± 3.14.8
94/14 (29)44.8 ± 1.3*4.2 ± 0.9§8.4 ± 2.23.4
1012/12 (100)42.0 ± 1.1*5.7 ± 0.4*23.2 ± 3.5§3.4
F129/30 (97)56.4 ± 0.5*9.7 ± 4.3§54.6 ± 5.4*4.8
NZO6/10 (60)55.6 ± 0.9*34.5 ± 4.5*71.8 ± 3.8*4.9
NON0/9 (0)31.7 ± 0.81.5 ± 0.311.6 ± 2.13.3
  • Data are n (%), means ± SEM, and %. Comparative body weights are shown at 16 rather than 24 weeks because chronically diabetic males between 16 and 24 weeks may lose weight. Food consumption measured at 6 weeks of age during the period of the most rapid weight gain.

  • *

    * Significantly different from NON/Lt (P < 0.0023);

  • significantly different from NZO/HILt (P < 0.0023);

  • §

    § suggestive significant difference from NON/Lt (P < 0.05).