TABLE 1

Crude and adjusted trait heritabilities

Mean glucoseFasting glucoseHbA1c
Subjects with trait (n)1,4611,251771
Crude0.50 ± 0.060.38 ± 0.070.39 ± 0.09
Age-adjusted0.51 ± 0.060.42 ± 0.070.29 ± 0.08
Age- and BMI-adjusted0.49 ± 0.060.36 ± 0.070.33 ± 0.09
Multivariate-adjusted0.52 ± 0.060.38 ± 0.070.22 ± 0.08
Multivariate- and BMI-adjusted0.51 ± 0.060.34 ± 0.070.27 ± 0.09
  • Data are heritability ± SE, unless otherwise indicated. Traits adjusted using sex-specific linear regression models; standardized residuals from models were ranked and heritabilities SE ± were obtained from variance components analysis of ranked deviates. Multivariate models included terms for age, age2, age4, cigarette smoking, alcohol consumption, physical activity, and estrogen replacement therapy (among women).