TABLE 1

Comparison of parameters for NN304 and human insulin identified by iterative curve fitting (and associated CV) or calculated from identified parameters

NN304
Human insulin
ValueCV (%)ValueCV (%)
k01 (min−1)0.027 ± 0.0023.4 ± 0.40.28 ± 0.0223 ± 3
k02 (min−1)0.011 ± 0.0027.6 ± 1.70.014 ± 0.0027.3 ± 0.6
k21 (min−1)0.003 ± 0.0018.4 ± 1.60.043 ± 0.00521 ± 3
V1 (l)1.6 ± 0.13.1 ± 0.41.6 ± 0.224 ± 3
k12 (min−1)0.0011 ± 0.00020.018 ± 0.002
  • Data are means ± SD.