TABLE 1

Clinical characteristics of study subjects

ParametersProtocol 1
Protocol 2
Type 2 diabetic subjectsControl subjectsType 2 diabetic co-twinsNondiabetic co-twinsControl subjects
n (F/M)6 (1/5)6 (0/6)12 (5/7)12 (5/7)12 (6/6)
Age (years)51 ± 448 ± 964 ± 364 ± 361 ± 2
BMI (kg/m2)25.1 ± 2.727.1 ± 4.230.1 ± 1.327.5 ± 1.326.0 ± 1.0
Fasting plasma glucose (mmol/l)8.9 ± 0.8*5.7 ± 0.211.4 ± 1.1*6.0 ± 0.25.4 ± 0.2
Fasting plasma insulin (μU/ml)NDND12.7 ± 1.6*7.3 ± 2.26.9 ± 0.9
2-h glucose (mmol/l)NDND19.5 ± 1.7*8.1 ± 1.65.7 ± 0.3
Glucose uptake (mg · kg FFM−1 · min−1)2.8 ± 1.26.8 ± 2.25.2 ± 0.7*8.5 ± 0.811.3 ± 0.9
Glucose storage (mg · kg FFM−1 · min−1)NDND2.8 ± 0.6*4.8 ± 0.67.6 ± 0.9
Glucose oxidation (mg · kg FFM−1 · min−1)NDND2.4 ± 0.2*3.7 ± 0.23.8 ± 0.2
Lipid oxidation (mg · kg FFM−1 · min−1)NDND1.23 ± 0.13*0.76 ± 0.180.65 ± 0.07
  • Data are means ± SD. ND, not determined in the study.

  • *

    * P < 0.01 compared with control subjects

  • P < 0.02 compared with control subjects;

  • P < 0.05 compared with control subjects