TABLE 1

Morphological parameters and circulating metabolite concentrations in fed 6- and 12-month-old lean and obese Zucker rats

RatsAge (months)nMorphology
Metabolites
Body weight (g)Heart weight (g)Heart/body weight ratio (×103)Glucose (mmol/l)FFA (mmol/l)TG (mmol/l)
Lean
613362 ± 101.36 ± 0.043.78 ± 0.069.0 ± 0.30.13 ± 0.021.1 ± 0.1
1211505 ± 101.77 ± 0.123.60 ± 0.199.8 ± 0.30.17 ± 0.051.1 ± 0.1
Obese
68568 ± 15*1.67 ± 0.04*3.08 ± 0.06*10.3 ± 0.40.60 ± 0.07*3.3 ± 0.3*
1211740 ± 12*2.43 ± 0.07*3.16 ± 0.07*10.3 ± 0.50.65 ± 0.14*4.4 ± 0.6*
Lean RSG-treated
614368 ± 111.34 ± 0.033.73 ± 0.069.0 ± 0.40.08 ± 0.010.8 ± 0.1
1215519 ± 181.90 ± 0.123.69 ± 0.158.7 ± 0.20.13 ± 0.010.7 ± 0.1
Obese RSG-treated
610565 ± 10*1.67 ± 0.05*3.09 ± 0.07*8.8 ± 0.50.22 ± 0.041.7 ± 0.1
1212743 ± 16*2.49 ± 0.03*3.33 ± 0.14*8.8 ± 0.40.31 ± 0.062.5 ± 0.5
  • Data are means ± SE.

  • *

    * P < 0.05 vs. lean untreated,

  • P < 0.05 vs. obese untreated. All statistical comparisons were made to rats of the same age. RSG, rosiglitazone.