TABLE 2

Coronary flow rates, heart rates, and developed pressures pre- and post-ischemia in 6-and 12-month-old lean and obese Zucker rat hearts

RatsAge (months)nCoronary flow
Heart rate
Developed pressure
Pre-ischemiaPost-ischemiaPre-ischemiaPost-ischemiaPre-ischemiaPost-ischemia
(ml/min)(beats/min)(mmHg)
Lean
6523 ± 121 ± 1250 ± 9234 ± 12150 ± 9129 ± 7
12725 ± 125 ± 1231 ± 15235 ± 18145 ± 8115 ± 6
Obese
6526 ± 126 ± 1230 ± 14216 ± 10184 ± 9148 ± 14
12729 ± 129 ± 1187 ± 20158 ± 36168 ± 1270 ± 17*
Lean RSG-treated
6523 ± 123 ± 1276 ± 13254 ± 15164 ± 8128 ± 11
12724 ± 223 ± 2226 ± 17213 ± 25144 ± 6123 ± 6
Obese RSG-treated
6527 ± 226 ± 2228 ± 15212 ± 9169 ± 7133 ± 15
12729 ± 128 ± 2194 ± 14178 ± 18156 ± 3137 ± 12
  • Data are means ± SEM.

  • *

    * P < 0.05 vs. lean untreated,

  • P < 0.05 vs. obese untreated. All statistical comparisons were made to rats of the same age. RSG, rosiglitazone.