TABLE 5

Results of multipoint analyses showing loci with nominal evidence of linkage (MLS >1.17) in the whole population and two predefined subsets their empirical P values

Cytogenetic locationCalculated peak position (cM)Adjacent markerSubsetMLSNominal P valuePemp-uncorrected (1 trait)Pemp-corrected (3 traits)
1p36-p3257.13D1S199Whole1.530.006990.760.99
2q34233.87D2S325Whole1.680.004700.660.96
3q26-q28216.73D3S1565Whole1.380.010020.860.99
6p2323.75D6S289Whole1.520.007180.760.99
7p22-p2110.29D7S517Whole1.800.003540.580.91
11p13-p1254.23D11S935Whole3.08*0.000170.070.20
15q13-q2142.75D15S994Whole2.190.001380.320.70
20q12-q1366.15D20S119Whole1.670.004890.660.96
1p36-p3285.55D1S2797Lean301.580.006170.97
2q34223.33D2S117Lean302.41*0.000820.51
2q36261.76D2S396Young-Onset451.680.004730.96
3p14110.48D3S1566Young-Onset451.730.004260.95
4q31201.34D4S415Young-Onset451.630.005470.97
7p22-p2110.29D7S517Lean303.51*0.000060.082
11p13-p1254.23D11S935Lean303.00*0.000200.23
14q11-q1324.51D14S275Young-Onset452.37*0.000900.52
15q13-q2142.36D15S994Young-Onset453.910.000020.034
15q13-q2142.36D15S994Lean302.44*0.000760.5
18q23135.66D18S70Young-Onset451.520.007150.98
19q1393.26D19S571Young-Onset451.690.004660.96
20q12-q1366.15D20S119Lean302.32*0.001020.53
  • *

    * Supporting suggestive linkage (LOD >2.2, P < 0.0007) according to genome-wide criteria;

  • supporting significant linkage (LOD > 3.6, P < 0.00002) according to genome-wide criteria.