TABLE 2

Mean ± SE serum nonesterified fatty acids and blood β-hydroxybutyrate, lactate, and alanine concentrations during low-dose stepped hyperinsulinemic euglycemic clamps (Eu), stepped hypoglycemic (4.7, 4.2, 3.6, and 3.0 mmol/l) clamps (Hypo), and stepped hypoglycemic clamps with tolbutamide 1.0 g/h (Hypo + Tolb) from 60 to 300 min

Time (min)
P*
−15060120180240300
Nonesterified fatty acids (μmol/l)
 Eu592 ± 50586 ± 43522 ± 55274 ± 29136 ± 15101 ± 11101 ± 12
 Hypo487 ± 47512 ± 69445 ± 46260 ± 40157 ± 32118 ± 15110 ± 15
 Hypo + Tolb601 ± 56602 ± 52592 ± 55206 ± 20157 ± 18130 ± 16113 ± 130.3795
β-Hydroxybutyrate (μmol/l)
 Eu141 ± 35174 ± 43133 ± 2368 ± 856 ± 1338 ± 736 ± 6
 Hypo77 ± 14106 ± 2694 ± 2049 ± 852 ± 1638 ± 1131 ± 6
 Hypo + Tolb179 ± 60142 ± 48162 ± 4173 ± 962 ± 949 ± 1050 ± 90.3618
Lactate (μmol/l)
 Eu775 ± 85872 ± 103805 ± 131878 ± 78966 ± 781,078 ± 1291,130 ± 125
 Hypo1,074 ± 1281,049 ± 1321,186 ± 1561,169 ± 1381,214 ± 1751,079 ± 891,280 ± 129
 Hypo + Tolb889 ± 145749 ± 127839 ± 123933 ± 103816 ± 741,051 ± 711,516 ± 1170.0024
Alanine (μmol/l)
 Eu330 ± 66394 ± 75361 ± 78344 ± 77413 ± 92384 ± 77315 ± 48
 Hypo349 ± 39468 ± 56420 ± 54465 ± 67440 ± 59363 ± 51297 ± 44
 Hypo + Tolb518 ± 98414 ± 67485 ± 107410 ± 66374 ± 55376 ± 62334 ± 490.1792
  • *

    * Hypo versus Hypo + Tolb.