TABLE 4

Mean ± SE glucose infusion rates (μmol · kg−1 · min−1)* during low-dose stepped hyperinsulinemic euglycemic clamps (Eu), stepped hypoglycemic (4.7, 4.2, 3.6, and 3.0 mmol/l) clamps (Hypo), and stepped hypoglycemic clamps with tolbutamide 1.0 g/h (Hypo + Tolb) from 60 to 300 min (n = 12) and in a subset of subjects (n = 5) during higher dose insulin and otherwise identical stepped hypoglycemic clamps (Higher Ins, Hypo)

Time (min)
P
−15060120180240300
All subjects (n = 12)
 Eu001.4 ± 0.65.1 ± 1.418.5 ± 1.836.5 ± 2.647.2 ± 2.7
 Hypo001.5 ± 0.64.0 ± 1.712.1 ± 2.618.9 ± 2.818.3 ± 3.7
 Hypo + Tolb002.5 ± 0.914.8 ± 2.432.5 ± 2.739.6 ± 2.630.6 ± 4.3<0.0001
Subset of subjects (n = 5)
 Eu001.2 ± 0.82.3 ± 1.320.4 ± 3.839.9 ± 4.448.1 ± 4.4
 Hypo001.3 ± 0.85.4 ± 4.116.7 ± 4.819.5 ± 5.519.2 ± 8.5
 Hypo + Tolb001.4 ± 0.917.4 ± 2.931.6 ± 5.137.2 ± 4.832.1 ± 8.30.0331
 Higher Ins, Hypo001.6 ± 1.218.3 ± 4.733.5 ± 3.534.5 ± 3.020.0 ± 5.60.0045
  • *

    * To convert μmol · kg−1 · min−1 to mg · kg−1 · min−1, divide by 5.551;

  • Hypo versus Hypo + Tolb;

  • Hypo versus Higher Ins, Hypo.