TABLE 3

TDT results from 152 parent-offspring trios

CodonAllele/haplotype* (frequency)TransmittedUntransmittedNominal P valueTransmitted rate (95% CI)
341T (0.08)24170.270.59 (0.43–0.74)
456R (0.94)23110.040.68 (0.52–0.83)
611H (0.58)87630.050.58 (0.50–0.66)
774A (0.07)22190.640.54 (0.38–0.69)
855A (0.28)52660.200.44 (0.35–0.53)
1-R-H-1-1 (0.54)0.057
2-R-R-2-1 (0.06)0.83
1-R-R-1-2 (0.27)0.265
X-R-H-X-X (0.56)0.032
X-R-R-X-X (0.38)0.08
  • *

    * Amino acid symbol given if variant nonsynonymous. Analysis of haplotypes was limited to those consisting of all five variants that occur with a frequency >0.05, and those consisting of the two nonsynonymous variants that individually were nominally significant (and had a frequency >0.05). Allele 1, common allele; allele 2, rare allele. Haplotypes in sequence 341-456-611-774-855.

  • significance at 0.05 level if 95% Cls do not cross 0.5 (expected transmission rate).