TABLE 4

Summary of pooled analysis of H611R

Allele frequency
Genotype n (frequency)
nHHHHRRR
Case subjects
 Trios probands1520.6261 (0.42)65 (0.43)26 (0.17)
 YT2D1700.5957 (0.34)85 (0.50)28 (0.16)
 Type 2 diabetes1570.6061 (0.39)66 (0.42)30 (0.19)
 Total case subjects4790.60179 (0.38)216 (0.45)84 (0.18)
Control subjects
 Untransmitted trios chromosomes1520.5443 (0.28)79 (0.52)30 (0.20)
 Population control subjects3570.55115 (0.32)162 (0.45)80 (0.22)
 Total control subjects5090.55158 (0.31)241 (0.48)110 (0.22)
 OR (95% CI)1.24 (1.03–1.48)*
P0.0200.07
  • *

    * Based on allele frequency differences between case and control subjects;

  • based on a χ2 test of all three genotypes between case and control subjects.