TABLE 3

Type 2 diabetes islet secretory characteristics

SubjectInsulin release
n
3 mmol/l glucose
11 mmol/l glucose
11 mmol/l glucose + 1 mmol/l tolbutamide
(pmol · g−1 · s−1)(osc · min−1)(pmol · g−1 · s−1)(osc · min−1)(pmol · g−1 · s−1)(osc · min−1)
NIDDM: 12.8 ± 0.70.30 ± 0.0111.1 ± 1.80.28 ± 0.013.4 ± 0.90.27 ± 0.013
NIDDM: 210.9 ± 2.20.21 ± 0.0415.2 ± 2.60.18 ± 0.0268.3 ± 36.10.25 ± 0.025
NIDDM: 318.5 ± 2.80.28 ± 0.0119.9 ± 2.90.26 ± 0.0122.0 ± 2.90.27 ± 0.018
  • Data are means ± SE for the number (n) of islets perifused from each subject. Islets isolated from subjects with type 2 diabetes were perifused in the presence of 3 and 11 mmol/l glucose and 11 mmol/l glucose and 1 mmol/l tolbutamide. The perifusate was sampled every 20 s and analyzed for insulin content and oscillatory activity.