TABLE 5

Proportion (95% CI) of incident patients with type 1 diabetes who are antibody positive by age category

Age at clinical onset (years)
0–67–1314–2021–2728–34
IAA
0.69 (0.60–0.79)0.41 (0.34–0.48)0.24 (0.15–0.032)0.19 (0.10–0.29)0.13 (0.06–0.22)
GADA by number of DQ2 haplotypes
 00.28 (0.14–0.42)0.44 (0.35–0.52)0.42 (0.30–0.55)0.62 (0.47–0.74)0.63 (0.49–0.76)
 10.51 (0.39–0.63)0.63 (0.54–0.72)0.61 (0.49–0.73)0.69 (0.56–0.81)0.66 (0.48–0.83)
 20.75 (0.25–1.00)0.75 (0.25–1.00)0.89 (0.67–1.00)0.62 (0.25–0.88)0.25 (0.00–0.75)
ICA512/IA-2A
0.68 (0.59–0.77)0.72 (0.67–0.78)0.56 (0.47–0.64)0.40 (0.31–0.50)0.30 (0.21–0.40)
ICA
0.89 (0.83–0.95)0.85 (0.81–0.90)0.77 (0.70–0.84)0.68 (0.59–0.77)0.67 (0.57–0.77)
  • The purpose of the table is descriptive rather than inferential, and so no P values are reported. Statistical testing of hypotheses is deferred to the logistic regression analysis. Of the original 971 patients, 491 (51.0%), 652 (67.1%), 651 (67.0%), and 669 (68.9%) were analyzed for IAA, GADA, ICA512/IA-2A, and ICA, respectively (see Table 4).