TABLE 1

Effect of leptin treatment on female and male NOD mice

PBS-treatedLeptin-treated*P
Females
n2321
 Body weight (g)19.1 ± 1.1615.9 ± 1.1<0.001
 BG (mg/dl)110.0 ± 16.1327.0 ± 130.6<0.01
 Urinary acetoacetate (mg/dl)0.0 ± 0.023.0 ± 15.1<0.001
 Mortality0.0%33.3%<0.01
Males
n710
 Body weight (g)24.2 ± 3.3223.39 ± 2.63NS
 BG (mg/dl)121.7 ± 13.1112.4 ± 33.2NS
 Urinary acetoacetate (mg/dl)0.0 ± 0.00.0 ± 0.0NS
 Mortality0.0%0.0%NS
  • Data are means ± SD.

  • *

    * NOD mice were injected intraperitoneally with 1 μg/g body wt of mouse recombinant leptin or PBS starting from 1 week of age, weekly for the first 4 weeks of life. Beginning in the 4th week of age, injections were repeated every 36 h for 2 consecutive weeks until week 6. Body weight, BG, urinary acetoacetate, and mortality were scored weekly. The table shows these parameters at 6 weeks of age; data were accumulated and averaged from two separate experiments. NS, not significant.

  • Mann-Whitney U test.