TABLE 4

14C-P clearance/3H-R-BrP clearance ratios (Kfs′/(Kf*/LC*))

ControlHigh fat
Red gastrocnemius
 basal0.70 ± 0.080.72 ± 0.09
 clamp0.87 ± 0.100.74 ± 0.04
 intralipid0.90 ± 0.101.09 ± 0.14
Liver
 basal0.82 ± 0.050.99 ± 0.05*
 clamp1.27 ± 0.061.27 ± 0.06
 intralipid0.68 ± 0.040.80 ± 0.05
  • Data are means ± SE for rats studied under basal conditions, during hyperinsulinemic-euglycemic clamp or infusion of intralipid and heparin (n = 6–8 animals/group).

  • *

    * P < 0.05 compared with control.