TABLE 1

Insulin released by YK-14 cells with and without exposure to betacellulin

ConditionInsulin concentration (nmol/l)
Without betacellulin< 0.1
With betacellulin106.2 ± 6.6*
  • Data are mean and mean ± SD (n = 4). YK-14 cells were exposed to 2 nmol/l betacellulin for 6 days in cultured medium containing 5.6 mmol/l glucose. The spent culture medium was assayed for insulin concentration using RIA.

  • *

    * P < 0.01 vs. cells without betacellulin.