TABLE 2

Insulin release from control and Gly972 →Arg IRS-1 islets in response to different stimuli

Glucose
Glibenclamide 100 μmol/lArginine 20 mmol/l
1.8 mmol/l5.5 mmol/l16.7 mmol/l
Control1.4 ± 0.32.6 ± 1.64.3 ± 1.44.5 ± 1.62.6 ± 0.6
Gly972→Arg1.6 ± 0.41.9 ± 0.42.9 ± 1.1*3.5 ± 2.44.7 ± 1.3
  • Data are percent of insulin content and are means ± SD. ANOVA was performed to test differences in the response to stepwise increase of glucose concentrations, which was significantly higher (P < 0.05) in control islets.

  • *

    * P = 0.05,

  • P < 0.05 vs. control.