TABLE 3

Proinsulin secretion results from control and Gly972→Arg islets in response to different stimuli

Glucose
Glibenclamide 100 μmol/lArginine 20 mmol/l
1.8 mmol/l5.5 mmol/l16.7 mmol/l
Control1.46 ± 0.41.96 ± 0.32.64 ± 0.72.7 ± 0.92.5 ± 0.4
Gly972→Arg1.08 ± 0.70.90 ± 0.2*1.28 ± 0.8*1.5 ± 0.5*2.6 ± 0.5
  • Data are pmol/islet and are means ± SD. ANOVA was performed to test differences in the response to stepwise increase of glucose concentrations, which was significantly higher (P < 0.05) in control islets.

  • *

    * P < 0.05 vs. control.