TABLE 4

Glucose utilization and oxidation in islets isolated from subjects carrying the Gly972→Arg IRS-1 polymorphism and in control islets

Glucose (3.3 mmol/l)
Glucose (16.7 mmol/l)
UtilizationOxidationUtilizationOxidation
Control37.6 ± 5.918.3 ± 3.5118.2 ± 23.6*33.6 ± 6.8*
Gly972→Arg IRS-133.7 ± 3.615.3 ± 2.7105.4 ± 11.2*36.3 ± 4.4*
  • Data represent pmol · islet−1 · 120 min−1 and are means ± SD.

  • *

    * P < 0.05 vs. low glucose.