TABLE 5

Volume density and number of immature and mature secretory granules in beta-cells from control and Gly972→Arg IRS-1 islets

Volume density (% ml)
Number (per microscopy field)
ImmatureMatureImmatureMature
Control0.5 ± 0.23.5 ± 0.85.5 ± 0.862 ± 5
Gly972→Arg IRS-13.3 ± 0.7*0.9 ± 0.2*49 ± 6.5*11 ± 1.1*
  • Data are means ± SD.

  • *

    * P < 0.02 vs. control.